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The term entourage effect was introduced in 1999 and has developed to define the polypharmacy effects of mixed cannabis phytochemicals or whole plant extracts. In simple terms, it suggests that compounds in cannabis may work together to create a holistic approach to health and wellness “the sum of all the parts” philosophy and medicine.

The entourage effect is a proposed mechanism by which cannabis compounds other than tetrahydrocannabinol (THC) act synergistically with it to modulate the overall psychoactive effects of the plant. Grof, Christopher P. L. (24 May 2018).

Cannabis, from plant to pill”. British Journal of Clinical Pharmacology. 84 (11): 2463–2467. doi: 10.1111/bcp.13618. ISSN 0306-5251. PMC 6177712. PMID 29701252.


What is the Entourage Effect of Marijuana?

How does the entourage effect work?

The entourage effect is considered a possible cannabinoid system modulator and is achieved in pain management. Jerome, Bouaziz (April 1, 2017).

The Clinical Significance of Endocannabinoids in Endometriosis Pain Management“. Cannabis and Cannabinoid Research. 2 (1): 72–80. doi: 10.1089/can. 2016.0035. PMC 5436335. PMID 28861506.


What are the different compounds found in cannabis?

  • cannabinoids cannabidiol
  • tetrahydrocannabinol
  • terpenoids
  • flavonoids

Discoveries are being made more often as medical marijuana patients in dozens of states and countries expand access as an alternative to pharmaceuticals and scientific research.

What is the entourage effect of marijuana?

The entourage effect occurs as cannabis compounds interact with the body to produce a stronger effect than any isolated cannabis plant compound. As cannabinoid receptors are stimulated, a range of physiologic processes follow.

What are the main cannabinoids?

There are two most prominent cannabinoids in the cannabis plant are:

  • delta-9-tetrahydrocannabinol (THC)
  • cannabidiol (CBD)

THC is widely known for its psychoactive effects on the human body.

What is the endocannabinoid system?

The endocannabinoid system is found throughout the human body and appears to be involved in a holistic way of working on the whole of the body to help regulate and seek equilibrium. Some examples of how the entourage effect works include:

  • appetite
  • pain-sensation
  • mood
  • memory
  • immune system
  • nervous system
  • brain
  • organs
  • connective tissue
  • glands
  • immune cells

What are cannabinoid receptors and how do they work?

The entourage effect works Cannabinoid receptors – a group of cell membrane receptors in the G protein-coupled receptor superfamily.

With its complex actions in our immune system, nervous system, and virtually all of the body’s organs, the endocannabinoids are literally a bridge between body and mind. By understanding this system, we begin to see a mechanism that could connect brain activity and states of physical health and disease.

Getting High on the Endocannabinoid System byBradley E. Alger, Ph.D


How many cannabinoid receptors are in the human body?

Researchers have identified two cannabinoid receptors that play a part in the entourage effect:

  • CB1
    • present in the nervous system, connective tissues, gonads, glands, organs
  • CB2
    • found in the immune system

Are there cannabinoid receptors in the skin?

Recent research has discovered that cannabinoids have verifiable anti-inflammation properties when applied to the skin.

Cannabinoids exert anti-inflammatory effects in skin, through both their actions on keratinocyte cytokine production and their modulation of immune cells. … Thus, endocannabinoids and their receptors constitute part of an adaptive system to regulate cutaneous inflammation.

TRP Channel Cannabinoid Receptors in Skin Sensation, Homeostasis, and Inflammation by Michael J. Caterina


Still have questions about medical marijuana? Speak with a licensed doctor today!

Oklahoma FAQ: medical marijuana doctors https://elevate-holistics.com/faqs/medical-marijuana-oklahoma/

Missouri FAQ: medical marijuana doctors https://elevate-holistics.com/faqs/medical-marijuana-missouri/

Pennsylvania FAQ: how to get a medical marijuana card https://elevate-holistics.com/get-a-medical-marijuana-card/pennsylvania/

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About the author

Michael Lawal is a seasoned content writer with specialized expertise in the medical cannabis industry. With a background that blends journalism and health sciences, Michael has a knack for translating complex medical cannabis research into accessible and engaging content. His writing portfolio showcases a range of work from informative articles and research summaries to patient education materials. Committed to raising awareness about the benefits and responsible use of medical cannabis, Michael's work is a valuable resource for both consumers and professionals in the field.
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